The Peptidomimetic CXCR4 Antagonist TC14012 Recruits β-Arrestin to CXCR7
نویسندگان
چکیده
منابع مشابه
CXCR7 Controls Competition for Recruitment of β-Arrestin 2 in Cells Expressing Both CXCR4 and CXCR7
Chemokine CXCL12 promotes growth and metastasis of more than 20 different human cancers, as well as pathogenesis of other common diseases. CXCL12 binds two different receptors, CXCR4 and CXCR7, both of which recruit and signal through the cytosolic adapter protein β-arrestin 2. Differences in CXCL12-dependent recruitment of β-arrestin 2 in cells expressing one or both receptors remain poorly de...
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In addition to its well-known effect on migration and homing of hematopoietic stem/progenitor cells (HSPCs), CXCL12 chemokine also exhibits a cell cycle and survival-promoting factor for human CD34(+) HSPCs. CXCR4 was suggested to be responsible for CXCL12-induced biological effects until the recent discovery of its second receptor, CXCR7. Until now, the participation of CXCR7 in CXCL12-induced...
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The G(i/o)-coupled histamine H(4) receptor is highly expressed in hemopoietic cells and is a promising new target for the treatment of chronic inflammatory diseases. 1-[(5-Chloro-1H-indol-2-yl)carbonyl]-4-methyl-piperazine (JNJ7777120) has been described as a selective antagonist at the H(4) receptor and is widely used to characterize the physiological role of the H(4) receptor. We have investi...
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The importance of inflammation in the initiation and development of atherosclerosis has been extensively studied over the last decades.1,2 In particular, much effort has been devoted to elucidating the role of chemokines and their receptors, which play a central part in the atherogenic immune response. Indeed, interfering with the chemokine– chemokine receptor system emerged as both an exciting...
متن کاملβ-Arrestin Goes Nuclear
Arrestins are a family of scaffolding proteins that are closely associated with the function of seven transmembrane domain G protein-coupled receptors (GPCRs). In mammals, two members of the arrestin family, the visual arrestins, are restricted to photoreceptor cells, whereas two others, β-arrestin 1 and β-arrestin 2, are expressed ubiquitously. These proteins promote the internalization and de...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2010
ISSN: 0021-9258
DOI: 10.1074/jbc.c110.147470